ROGER W. ROBINSON, M.D.; WILLIAM D. COHEN, Ph.D.; NORIO HIGANO, M.D.
Coronary heart disease is rarely encountered in premenopausal women.1, 2 However, postmenopausally a sharp rise in the incidence of this disease has been reported in the sixth decade of life,3, 4 and by the seventh decade the incidence approaches that of men. A fundamental biochemical alteration associated with the menopause is the substantial decrease of ovarian estrogen production, as measured by urinary estrogen levels.5 Alterations of the serum lipids coincident with this low estrogen production have been reported. These include increases of serum cholesterol,6, 7 of cholesterol-phospholipid ratio,8, 9 and of β-/α-lipoprotein-cholesterol ratio.9 The frequent association of these abnormalities
ROBINSON RW, COHEN WD, HIGANO N. ESTROGEN REPLACEMENT THERAPY IN WOMEN WITH CORONARY ATHEROSCLEROSIS*. Ann Intern Med. 1958;48:95–101. doi: https://doi.org/10.7326/0003-4819-48-1-95
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Published: Ann Intern Med. 1958;48(1):95-101.
Cardiology, Coronary Heart Disease.
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