JAMES R. WARD; ROBERT C. HUNTER JR.
Granulomata in the liver have been previously demonstrated in tissue obtained by needle biopsy in such diseases as tuberculosis,1-8 sarcoidosis,2, 3, 9-14 Hodgkin's disease,3 lymphopathia venereum,3 tularemia,2, 3, 15 brucellosis,2, 3, 16, 17 syphilis,2, 3 leprosy,18 and fungus infections.14
When involvement of the liver occurs in these diffuse granulomatous diseases, the foci are usually widely scattered.5, 14, 16 Zamcheck and Sidman19 have reviewed various studies which indicate the validity of the liver biopsy specimen as a representative histologic sample in such conditions, and in summary state that needle biopsy accurately samples all diffuse anatomic lesions and the majority of focal
WARD JR, HUNTER RC. DISSEMINATED COCCIDIOIDOMYCOSIS DEMONSTRATED BY NEEDLE BIOPSY OF THE LIVER*. Ann Intern Med. 1958;48:157–163. doi: https://doi.org/10.7326/0003-4819-48-1-157
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Published: Ann Intern Med. 1958;48(1):157-163.
Gastroenterology/Hepatology, Infectious Disease, Liver Disease.
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