JOHN F. GRIFFIN, M.D.; GERALD M. KOMAN, M.D.
Although more than 10 years have elapsed since Baer, Taussig and Oppenheimer1 first drew attention to involvement of the aortic wall as a complication of Marfan's syndrome, relatively few autopsy reports have been published with anatomic descriptions of the defect. Recent pathologic studies reported by McKusick2 and others3, 4 have stressed the variety of cardiovascular lesions that may be associated with this syndrome.
Over 50 autopsied cases of Marfan's syndrome have now been reported. In 1951 Marvel reviewed the findings in the 28 autopsied cases reported up to that time.5 Table 1 summarizes the significant necropsy findings in 27 autopsied
GRIFFIN JF, KOMAN GM. SEVERE AORTIC INSUFFICIENCY IN MARFAN'S SYNDROME*. Ann Intern Med. 1958;48:174–187. doi: https://doi.org/10.7326/0003-4819-48-1-174
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Published: Ann Intern Med. 1958;48(1):174-187.
Cardiology, Valvular Heart Disease.
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