GERALD L. GLASER, M.D.; DONALD A. ADAMS, M.D.
Chlorpromazine has been widely administered for several years. Two of the most serious complications reported from its use are jaundice and agranulocytosis. Forty-five cases of the latter were collected in a report in 1956,1 and several more have been added since, with an estimated incidence of less than 0.3%. Other reviews of this problem have appeared recently in the literature.2, 3
Promazine† has been increasingly popular since the early favorable reports of its use in May, 1956.4, 5 It differs structurally from chlorpromazine only in the absence of a chloride radical in the 2-position of the phenothiazine ring. Reports of
GLASER GL, ADAMS DA. AGRANULOCYTOSIS ASSOCIATED WITH PROMAZINE ADMINISTRATION: REPORT OF THREE CASES1. Ann Intern Med. ;48:372–379. doi: 10.7326/0003-4819-48-2-372
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Published: Ann Intern Med. 1958;48(2):372-379.
Asthma, Cardiology, Coronary Heart Disease, Diarrhea, Gastroenterology/Hepatology.
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