LEONARD CARDON, M.D., F.A.C.P.; OSCAR H. COMESS, M.D.; THOMAS A. NOBLE, M.D.; MARK M. POMARANC, M.D.
Modern medical science has made such tremendous strides in the field of therapeutics that many older drugs, especially if potentially productive of untoward and dangerous side-effects, have been discredited and have fallen into disuse. Admittedly, many such drugs have marked therapeutic value and are deserving of further investigation and clinical trial before they are completely discarded.
Aminopyrine, by force of historical circumstances, has been such a discredited drug for many years.1, 2a, 3c, 4b, 5, 6, 7, 8 The danger of agranulocytosis resulting from its use is real and well established, but undoubtedly has been overemphasized.1, 2a, 4b, 5, 6,
CARDON L, COMESS OH, NOBLE TA, et al. VALUE OF AMINOPYRINE12. Ann Intern Med. 1958;48:616–634. doi: 10.7326/0003-4819-48-3-616
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Published: Ann Intern Med. 1958;48(3):616-634.
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