THEODORE RODMAN, M.D.; WILLIAM FRAIMOW, M.D.; RALPH M. MYERSON, M.D., F.A.C.P.
In 1932 and 1936 Löffler1, 2 described a syndrome, commonly associated with his name, characterized by transitory pulmonary infiltrations that are often migratory, eosinophilia, and a benign course with few symptoms. Since then experimental, clinical and pathologic evidence has been accumulated which supports the allergic nature of this syndrome. A wide variety of agents have been incriminated as allergens. Many reports describe Löffler's syndrome secondary to various helminthic infestations. Less frequently, cases have been reported in association with amebiasis,3 brucellosis,4 coccidioidomycosis,5 and following exposure to ragweed and privet pollen.6 The administration of drugs such as Prontosil,7 sulfonamides,8, 9 penicillin10, 11
RODMAN T, FRAIMOW W, MYERSON RM. LÖFFLER'S SYNDROME: REPORT OF A CASE ASSOCIATED WITH ADMINISTRATION OF MEPHENESIN CARBAMATE (TOLSERAM)*. Ann Intern Med. 1958;48:668–674. doi: https://doi.org/10.7326/0003-4819-48-3-668
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Published: Ann Intern Med. 1958;48(3):668-674.
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