FELIX WRÓBLEWSKI, M.D., F.A.C.P.; RITA WRÓBLEWSKI, M.D.
Observations from tissue culture studies suggest that malignant neoplastic cells contribute increasing amounts of lactic dehydrogenase (LD) activity to the fluid medium which bathes the cells.1 Similar activity by cancer cells in vivo is implied by observations made of LD activity in the serum and the peritoneal fluid of mice with Ehrlich's ascites carcinoma.2 The generalization that malignant tissue contributes LD activity to fluids which bathe them is implied clinically by the fact that LD activity of cerebrospinal fluid is increased above the normal range in spinal fluid specimens obtained from patients with cancer, lymphoma and leukemia.3
Pleural and
WRÓBLEWSKI F, WRÓBLEWSKI R. THE CLINICAL SIGNIFICANCE OF LACTIC DEHYDROGENASE ACTIVITY OF SEROUS EFFUSIONS*. Ann Intern Med. 1958;48:813–822. doi: https://doi.org/10.7326/0003-4819-48-4-813
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Published: Ann Intern Med. 1958;48(4):813-822.
DOI: 10.7326/0003-4819-48-4-813
Hematology/Oncology, Pulmonary/Critical Care.
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