NELSON RICHARDS; LORING F. CHAPMAN; HELEN GOODELL; HAROLD G. WOLFF, F.A.C.P.
In 1943 Hoffmann1 detected in himself strange mental effects from a compound that he and Stoll2 had prepared in 1938 and reported in 1943 as an oxytocic agent similar to ergonovine. This observation of the effect of lysergic acid diethylamide (LSD) led to the investigation of other derivatives of this compound in research on experimentally induced mental disorders.3 LSD and most of its related compounds have been found to produce an anti-5-hydroxytryptamine (serotonin) effect both peripherally and, it has been assumed, centrally by blocking the action of serotonin.3a
Cerletti and Rothlin4 have reported on a compound, 2-bromo-d-lysergic acid diethylamide,
RICHARDS N, CHAPMAN LF, GOODELL H, et al. LSD-LIKE DELIRIUM FOLLOWING INGESTION OF A SMALL AMOUNT OF ITS BROM ANALOG (BOL-148)12. Ann Intern Med. 1958;48:1078–1083. doi: 10.7326/0003-4819-48-5-1078
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Published: Ann Intern Med. 1958;48(5):1078-1083.
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