FOUAD A. BASHOUR, M.D.; DANIEL H. SIMMONS, M.D.
Criteria for the clinical differentiation of atrial septal defect in combination with mitral valvular disease from isolated septal defect have been suggested, based upon the degree of cardiomegaly and the size of the pulmonary conus.1, 2 The presence of a low-pitched rumbling apical diastolic murmur, presumably due to mitral valvular disease, has also been thought to be diagnostic of the combined lesion in cases in which the diagnosis of atrial septal defect had been established physiologically. This attitude was fostered by early studies of the autopsied cases of atrial septal defect reported in the literature which indicated a high incidence
BASHOUR FA, SIMMONS DH. ATRIAL SEPTAL DEFECT WITH MITRAL VALVULITIS: CLINICAL AND CATHETERIZATION DIAGNOSIS1. Ann Intern Med. 1958;48:194–1204. doi: 10.7326/0003-4819-48-6-1194
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Published: Ann Intern Med. 1958;48(6):194-1204.
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