THEODORE PESSAR, M.D., F.A.C.P.; JOHN W. HESSING, M.D.
Hepatic coma is a frequent terminal occurrence in advanced atrophic or postnecrotic cirrhosis. Coma can be precipitated in patients with pre-existing liver damage by hepatotoxic agents, infection, physical overactivity, improper use of sedatives or narcotics, inadequate diet, trauma or surgery.
Hepatic coma carries with it a high mortality. Murphy1 in his series of 42 cases had 40 deaths. Snell,2 in a series of cases reported from the Mayo Clinic, showed that 23 out of 54 cases of atrophic cirrhosis died in coma. Karl et al.,3 in a review of 58 cases of hepatic coma selected from the records of the
PESSAR T, HESSING JW. MASSIVE DOSES OF CORTISONE IN HEPATIC COMA*. Ann Intern Med. 1958;48:1253–1268. doi: https://doi.org/10.7326/0003-4819-48-6-1253
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Published: Ann Intern Med. 1958;48(6):1253-1268.
Encephalopathy, Gastroenterology/Hepatology, Liver Disease, Neurology.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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