HENRY H. HENSTELL, M.D.; MIRIAM KLIGERMAN, B.S.
A new theory of interference with the clotting mechanism was recently advanced by the authors, based on the observation that unusual plasma globulins complex with and/or coprecipitate clotting factors.12, 13 The consequence is a reduction or inactivation of clotting factors, resulting in hemorrhagic disorders of varying degree. In addition, an unstable clotting mechanism and/or increased local concentrations of clotting factors would result, causing an increased thrombotic tendency. This theory offers a reasonable explanation for bleeding diatheses such as occur in purpura hyperglobulinemica, macroglobulinemia, multiple myeloma, liver damage and other conditions characterized by production of unusual plasma globulins. It can
HENSTELL HH, KLIGERMAN M. A NEW THEORY OF INTERFERENCE WITH THE CLOTTING MECHANISM: THE COMPLEXING OF EUGLOBULIN WITH FACTOR V, FACTOR VII AND PROTHROMBIN12. Ann Intern Med. ;49:371–387. doi: 10.7326/0003-4819-49-2-371
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Published: Ann Intern Med. 1958;49(2):371-387.
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