HERBERT A. DANN, M.D.; HYMAN W. FISHER, M.D.; LEE BURNETT, M.S.; DONALD BRIGGS, M.D.
It became apparent a decade ago that the conversion of prothrombin to thrombin does not occur solely with the aid of thromboplastin and calcium. Ware and his colleagues1-4 separated a protein fraction from bovine serum, serum AC-globulin, which they thought resulted from the interaction of thrombin with a relatively inert precursor, plasma AC-globulin. This increased the velocity and amount of thrombin formation in an isolated system containing prothrombin, thromboplastin and calcium. Owren5 found a similar substance evolving during the coagulation process and called it factor VI. Alexander et al.6-9 reported on a prothrombin conversion accelerator in serum, SPCA. Milstone10
DANN HA, FISHER HW, BURNETT L, et al. CONGENITAL SERUM PROTHROMBIN CONVERSION ACCELERATOR (SPCA) DEFICIENCY*. Ann Intern Med. 1958;49:459–466. doi: https://doi.org/10.7326/0003-4819-49-2-459
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Published: Ann Intern Med. 1958;49(2):459-466.
Coagulopathies, Education and Training, Hematology/Oncology.
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