VICTOR A. MCKUSICK, M.D.
There is a clinical impression of long standing that heredity plays some role in the pathogenesis of all four major types of cardiovascular disease: atherosclerosis (including coronary artery disease), hypertension, susceptibility to rheumatic fever (and therefore to rheumatic heart disease), and congenital malformations of the cardiovascular system.
These are diseases of multifactorial causation. To point to a genetic factor in coronary artery disease does not deny the possible importance of diet, stress, cigarette smoking, etc. To point to a genetic factor in susceptibility to rheumatic fever does not deny the paramount importance of the streptococcus. If one demonstrates a hereditary
MCKUSICK VA. THE GENETIC ASPECTS OF CARDIOVASCULAR DISEASES1. Ann Intern Med. 1958;49:556–567. doi: 10.7326/0003-4819-49-3-556
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Published: Ann Intern Med. 1958;49(3):556-567.
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