JOHN E. DAFFNER, M.D.; CHARLES H. BROWN, M.D., F.A.C.P.
Although regional ileitis was recognized as a clinical entity by Crohn, Ginsburg and Oppenheimer1 26 years ago, much remains unknown concerning the etiology, pathogenesis and treatment of the disease.
Regional ileitis was defined by Crohn, Ginsburg and Oppenheimer1 as a recurrent granulomatous disease mainly affecting young adults. In the acute inflammatory phase, ulcerative lesions are prominent; later, thickening of the mucosa, scarring, intestinal obstruction and fistulas may be present. The terminal ileum chiefly is involved, although lesions may be present elsewhere in the small intestine. Regional enteritis may cross the ileocecal valve and involve the colon (ileocolitis). The disease is
DAFFNER JE, BROWN CH. REGIONAL ENTERITIS. I. CLINICAL ASPECTS AND DIAGNOSIS IN 100 PATIENTS12. Ann Intern Med. 1958;49:580–594. doi: 10.7326/0003-4819-49-3-580
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Published: Ann Intern Med. 1958;49(3):580-594.
Gastroenterology/Hepatology, Inflammatory Bowel Disease.
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