ROBERT M. KARK, F.A.C.P., F.R.C.P. (Lond.); CONRAD L. PIRANI, M.D.; VICTOR E. POLLAK, M.B., M.R.C.P.E.; ROBERT C. MUEHRCKE, M.D.; JOHN D. BLAINEY, M.D., M.R.C.P.
The metabolic, nutritional and clinical consequences of continued massive albuminuria constitute the nephrotic syndrome. Florid cases are readily recognized from infancy1, 2 to extreme old age,3 and the diagnosis can be confirmed rapidly in the laboratory by urinalysis and simple biochemical studies of the blood. The nephrotic syndrome was first described by Richard Bright,4 who noted the association of proteinuria, hypoproteinemia and lipemia with edema of renal origin, and it has long been recognized as one manifestation of glomerulonephritis. From our experience with 98 adult patients studied by renal biopsy it is apparent that the syndrome may be due to
KARK RM, PIRANI CL, POLLAK VE, et al. THE NEPHROTIC SYNDROME IN ADULTS: A COMMON DISORDER WITH MANY CAUSES1. Ann Intern Med. 1958;49:751–774. doi: 10.7326/0003-4819-49-4-751
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Published: Ann Intern Med. 1958;49(4):751-774.
Nephrology, Nephrotic Syndrome.
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