NIMR A. TUQAN, M.D.
Periodic disease, periodic idiopathic abdominalgia or periodic peritonitis is a disease of unknown cause characterized by short attacks of pain in the abdomen or elsewhere and associated with fever and leukocytosis. Such attacks recur regularly or irregularly over many years. During such attacks an acute inflammatory process involves the visceral and parietal peritoneum.1 It is rather odd that intestinal adhesions, and consequent intestinal obstruction, do not occur in these patients despite the constant repetition of the serosal inflammatory lesions.
A number of these patients develop a "nephropathy"2 after a few years and may die with renal failure. The cause
TUQAN NA. PERIODIC DISEASE: A CLINICOPATHOLOGIC STUDY1. Ann Intern Med. ;49:885–899. doi: 10.7326/0003-4819-49-4-885
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Published: Ann Intern Med. 1958;49(4):885-899.
Lupus Erythematosus, Rheumatology.
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