ROBERT P. ARTHUR, M.D.; WALTER B. SHELLEY, M.D., F.A.C.P.
The purpose of this paper is to present a controlled study of pruritus in dermatitic skin. Recent experimental work has greatly enlarged our knowledge of this troublesome sensation in normal human subjects. A summary of this work will explain the new testing methods developed for use in this report, as well as provide a background understanding of itching mechanisms and responses.
Until recently, histamine was the standard material for experimentally inducing a measurable pruritus. The patient's sensitivity was determined by finding the threshold dilution. Indeed, many workers, following Sir Thomas Lewis, considered histamine as the probable direct chemomediator of
ARTHUR RP, SHELLEY WB. THE NATURE OF ITCHING IN DERMATITIC SKIN1. Ann Intern Med. ;49:900–908. doi: 10.7326/0003-4819-49-4-900
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Published: Ann Intern Med. 1958;49(4):900-908.
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