J. W. KINGSLEY JR., M.D.; REBECCA B. AQUINO, M.D.
Thrombotic thrombocytopenic purpura is an uncommon condition characterized by thrombocytopenia, hemolytic anemia and widespread occlusions of arterioles and capillaries. The vascular occlusions affect the central nervous system to a particularly great degree, producing diverse neurologic signs and symptoms. The earliest report of this disease was by Moschcowitz in 1925 under the title, "An Acute Febrile Pleochromic Anemia with Hyaline Thrombosis of the Terminal Arterioles and Capillaries."1 Several other descriptive terms were employed until 1947, when "thrombotic thrombocytopenic purpura" was proposed by Singer et al.2 Although this designation fails to emphasize the hemolytic factor, it is the term most commonly used
KINGSLEY JW, AQUINO RB. THROMBOTIC THROMBOCYTOPENIC PURPURA: REPORT OF A CASE AND REVIEW OF THE LITERATURE*. Ann Intern Med. 1958;49:934–941. doi: https://doi.org/10.7326/0003-4819-49-4-934
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Published: Ann Intern Med. 1958;49(4):934-941.
Coagulopathies, Hematology/Oncology, Platelet Disorders.
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