ERNEST L. WYNDER, M.D.; JEFFREY H. FRYER, M.B., B.S.
Plummer-Vinson syndrome, as classically described, occurs mostly in women and is characterized by smooth, thin facial skin; a narrow mouth, often termed a "fish-mouth," with a tendency to fissuring at the angles; a smooth tongue; brittle nails that may be spoon-shaped, particularly on the thumb and first three fingers; a past or present history of anemia and dysphagia, often of long duration, and there is also the likelihood of complete edentia. Of these features of the syndrome, only dysphagia is an absolute requirement for diagnosis; furthermore, characteristic anatomic changes in the hypopharynx and upper esophagus must be demonstrated to be
WYNDER EL, FRYER JH. ETIOLOGIC CONSIDERATIONS OF PLUMMER-VINSON (PATERSON-KELLY) SYNDROME*. Ann Intern Med. 1958;49:1106–1128. doi: https://doi.org/10.7326/0003-4819-49-5-1106
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Published: Ann Intern Med. 1958;49(5):1106-1128.
Esophageal Disorders, Gastroenterology/Hepatology.
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