RICHARD E. LEE; ARTHUR W. SELIGMANN; MELVA A. CLARK; NEMAT O. BORHANI; JOHN T. QUEENAN; MAUREEN E. O'BRIEN
Although the great majority of hypertensive patients can be managed effectively with presently established medical programs,1, 2 instances of failure to respond to treatment in a completely satisfactory manner are not uncommon. In our experience, such patients may include as many as 10% or more of the hypertensive population.3 Major reasons for such "refractoriness" are probably at least twofold: (1) predisposition to intolerance of drug side-effects that prevents use of antihypertensive agents in adequate amounts, and (2) perhaps a more fixed or resistant type of blood pressure elevation that is not amenable to the therapy employed. Within the last
LEE RE, SELIGMANN AW, CLARK MA, et al. THERAPEUTICALLY "REFRACTORY" HYPERTENSION: CAUSATIVE FACTORS, AND MEDICAL MANAGEMENT WITH CHLOROTHIAZIDE AND OTHER AGENTS1. Ann Intern Med. 1958;49:1129–1137. doi: 10.7326/0003-4819-49-5-1129
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Published: Ann Intern Med. 1958;49(5):1129-1137.
Cardiology, Coronary Risk Factors, Hypertension, Nephrology.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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