DAVID C. MILLER, M.D.; MARTHA F. TRULSON, D.SC.; MARY B. MCCANN, M.P.H.; PAUL D. WHITE, M.D., M.A.C.P.; FREDRICK J. STARE, M.D.
The hypothesis that ingestion of excess dietary fat leads to coronary arterial and heart disease is man is supported by much suggestive evidence but has yet to be demonstrated by rigorous proof. Atherosclerosis, including coronary atherosclerosis, has been induced in a variety of animals by different experimental regimens. Generally these involved the feeding of cholesterol and a high intake of fat. Under certain conditions the latter causes hypercholesterolemia and hyperlipoproteinemia in man, but firm evidence is lacking that coronary heart disease in man is caused by either overnutrition of fat or by over- or undernutrition of any other nutrient.1
MILLER DC, TRULSON MF, MCCANN MB, et al. DIET, BLOOD LIPIDS AND HEALTH OF ITALIAN MEN IN BOSTON1. Ann Intern Med. 1958;49:1178–1200. doi: 10.7326/0003-4819-49-5-1178
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Published: Ann Intern Med. 1958;49(5):1178-1200.
Cardiology, Coronary Risk Factors, Dyslipidemia.
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