HARRY SHAY, M.D., F.A.C.P.; DAVID C. H. SUN, M.D., D.SC. (Med.)
The hydrazine derivatives of isonicotinic acid (isoniazid and iproniazid) have been used effectively in the treatment of human tuberculosis. However, significant side-effects have occurred in patients under treatment with these compounds, particularly with iproniazid.1-4 These included euphoria, nervousness, restlessness, involuntary muscle twitching, hyperreflexia and mild clonus, peripheral neuritis, headache and vertigo. Occasionally, progressive hemolytic anemia and orthostatic hypotension with syncope have been reported from the use of iproniazid.5
Iproniazid phosphate, 1-isonicotinyl-2-isopropyl-hydrazine phosphate, has recently been suggested as a "psychic energizer," to restore a feeling of well-being, to promote increase in appetite, weight and vitality, and for use in patients with
SHAY H, SUN DCH. MASSIVE NECROSIS OF THE LIVER FOLLOWING IPRONIAZID*. Ann Intern Med. 1958;49:1246–1252. doi: https://doi.org/10.7326/0003-4819-49-5-1246
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Published: Ann Intern Med. 1958;49(5):1246-1252.
Gastroenterology/Hepatology, Liver Disease.
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