LAWRENCE E. HINKLE JR., M.D.; HAROLD G. WOLFF, M.D., F.A.C.P.
By the beginning of the present decade there was enough clinical and experimental evidence to establish the fact that a man's reactions to the situations that he encounters in his daily life may affect a great number of his internal processes. In effect, it was clear that any bodily function subject to the regulation of the central nervous system might be influenced to a significant degree, and that the regulatory influences of the central nervous system might be mediated directly by way of the neural pathways or internal secretions, or indirectly by way of changes in the over-all behavior of
HINKLE LE, WOLFF HG. ECOLOGIC INVESTIGATIONS OF THE RELATIONSHIP BETWEEN ILLNESS, LIFE EXPERIENCES AND THE SOCIAL ENVIRONMENT1. Ann Intern Med. 1958;49:1373–1388. doi: 10.7326/0003-4819-49-6-1373
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Published: Ann Intern Med. 1958;49(6):1373-1388.
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