JAMES M. SCHLESS, M.D.; HAROLD N. HARRISON; JAMES A. WIER
It has long been axiomatic that primary pleural effusion in tuberculin-positive individuals must be considered to be tuberculous until proved otherwise. The basis for this axiom arose in the pre-chemotherapy era when an appallingly high breakdown rate with significant tuberculous manifestations was noted in patients with pleural effusions followed for over five years.
Roper and Waring, 1 for instance, reported an over-all five-year breakdown rate of 65.2% in 141 patients treated in Army hospitals in the years 1944 and 1945. The breakdown rate was 90.9% in those patients in their series treated with less than six months of bed-rest,
SCHLESS JM, HARRISON HN, WIER JA. THE ROLE OF THORACOTOMY IN THE DIFFERENTIAL DIAGNOSIS OF PLEURAL EFFUSION1. Ann Intern Med. 1959;50:11–33. doi: 10.7326/0003-4819-50-1-11
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Published: Ann Intern Med. 1959;50(1):11-33.
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