JOHN A. COLWELL
Therapy has not previously altered the relentless progression of disseminated coccidioidomycosis. More than 50% mortality1 continues despite treatment with a variety of agents.2, 4 In the last year a new antibiotic, amphotericin B,2 has been released to clinical investigators. In vitro studies3, 4 have shown good antifungal properties of this Streptomyces derivative. Encouraging results have been described in studies with animals.5, 6, 7, 8 Several reports4, 9-16 of effectiveness in disseminated coccidioidomycosis have recently appeared. The present paper describes a mycologic and clinical remission in a case of disseminated coccidioidomycosis produced by prolonged intravenous therapy with amphotericin B.
COLWELL JA. REMISSION IN DISSEMINATED COCCIDIOIDOMYCOSIS PRODUCED BY AMPHOTERICIN B1. Ann Intern Med. 1959;50:1028–1035. doi: 10.7326/0003-4819-50-4-1028
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Published: Ann Intern Med. 1959;50(4):1028-1035.
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