PHILIP LISAN, M.D.; ATTILIO REALE, M.D.; WILLIAM LIKOFF, M.D., F.A.C.P.
A phasic recurrent fever occurring at variable times, mainly after mitral valve surgery, associated with incisional and/or pleuritic pain, has been called the postmitral commissurotomy syndrome. The etiology of this peculiar syndrome is unknown, but speculation has ranged from rheumatic reactivation and idiopathic pleuropericarditis to a hypersensitivity reaction from nonspecific antigens such as blood in the pleural or pericardial sacs postoperatively.1, 2
Considerable evidence favors the view that the postmitral commissurotomy syndrome represents reactivation of the rheumatic state.3, 4 The temperature elevation is low grade and cyclic, and is associated with myalgias or true migrating polyarthralgias. It is accompanied by
LISAN P, REALE A, LIKOFF W. THE POSTMITRAL COMMISSUROTOMY SYNDROME: A FOUR-YEAR CLINICAL, PATHOLOGIC AND SEROLOGIC STUDY, AND ITS RELATION TO RESTENOSIS*. Ann Intern Med. 1959;50:1352–1358. doi: https://doi.org/10.7326/0003-4819-50-6-1352
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Published: Ann Intern Med. 1959;50(6):1352-1358.
Cardiology, Valvular Heart Disease.
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