Skip Navigation
Menu
Original Research |1 June 1959

PLASMA PROTHROMBIN IN LIVER DISEASE: ITS CLINICAL AND PROGNOSTIC SIGNIFICANCE1

GORDON MINDRUM, M.D.; HELEN I. GLUECK, M.D., F.A.C.P.

FULL TEXT

Abstract

It is a well known clinical observation that a low concentration of plasma prothrombin which does not respond to the administration of vitamin K indicates serious liver disease.1-10 The usefulness of this observation is limited, however, by the fact that many patients with severe hepatic disease may have normal concentrations of prothrombin when the one-stage assay methods are utilized.2, 3, 5, 11, 12, 13 The two-stage procedures often detect hypoprothrombinemia in this disorder when the one-stage determination is normal or only slightly depressed.5, 13, 14, 15, 16

We have made similar observations in a large group of patients with various

FULL TEXT
PDF
Not Available
Citations
Citation

MINDRUM G, GLUECK HI. PLASMA PROTHROMBIN IN LIVER DISEASE: ITS CLINICAL AND PROGNOSTIC SIGNIFICANCE1. Ann Intern Med. 1959;50:1370–1384. doi: 10.7326/0003-4819-50-6-1370

Download citation file:

© 2019

×
Permissions

Published: Ann Intern Med. 1959;50(6):1370-1384.

DOI: 10.7326/0003-4819-50-6-1370

39 Citations

Related Articles
Clearance from Plasma of 4-C14-Estradiol-17 Beta in Patients with Hepatic Disease.
Annals of Internal Medicine; 58 (4): 724
THE PROTHROMBIN RESPONSE TO LARGE DOSES OF SYNTHETIC VITAMIN K IN LIVER DISEASE1
Annals of Internal Medicine; 22 (6): 841-851
The International Normalized Ratio (INR) for Monitoring Warfarin Therapy: Reliability and Relation to Other Monitoring Methods
Annals of Internal Medicine; 120 (7): 552-558
Presence of Human Hepegivirus-1 in a Cohort of People Who Inject Drugs
Annals of Internal Medicine; 167 (1): 1-7
View MoreView Less

Journal Club
4F-PCC was noninferior to plasma in patients with acute major bleeding who needed urgent VKA reversal
Annals of Internal Medicine; 160 (8): JC6
Review: Limited evidence suggests that statins are safe in patients with liver disease
Annals of Internal Medicine; 149 (4): JC2-12
View MoreView Less

Related Topics
Gastroenterology/Hepatology
Liver Disease

Gastroenterology/Hepatology, Liver Disease.

PubMed Articles
Coil valve syndrome: a rare complication of percutaneous transhepatic obliteration successfully treated by argon plasma coagulation and double-balloon endoscopy.
Endoscopy 2019.
Direct-Acting Oral Anticoagulants (DOACs) in Cirrhosis and Cirrhosis-Associated Portal Vein Thrombosis.
Semin Liver Dis 2019.
View More

Results provided by: PubMed

CONTINUE WITH LIMITED ACCESS
Annals of Internal Medicine
To receive access to the full text of freely available articles, alerts, and more. You will be directed to acponline.org to complete your registration.
×
acp link acp
silverchair link silverchair

Copyright © 2019 American College of Physicians. All Rights Reserved.

Print ISSN: 0003-4819 | Online ISSN: 1539-3704

Privacy Policy

|

Conditions of Use

This site uses cookies. By continuing to use our website, you are agreeing to our privacy policy. | Accept
×

You need a subscription to this content to use this feature.

×
PDF Downloads Require Access to the Full Article.
Annals of Internal Medicine
To receive access to the full text of freely available articles, alerts, and more. You will be directed to acponline.org to complete your registration.
×
Access to this Free Content Requires Users to be Registered and Logged In. Please Choose One of the Following Options
Annals of Internal Medicine
To receive access to the full text of freely available articles, alerts, and more. You will be directed to acponline.org to complete your registration.
×