JAMES B. HUDSON, M.D.; JOHN F. WHITCOMB, M.D.; WALTER E. JUDSON, M.D.; NORMAN H. BOYER, M.D., F.A.C.P.
Endocardial thickening by excessive fibrous and elastic tissue proliferation in infants and young children with enlargement of the heart and congestive failure is now a fairly well recognized clinical entity.
The concept of prenatal infection as an important cause of such cardiac anomalies was introduced by Kreysig,1 and the etiologic relationship of "fetal endocarditis" to this endocardial thickening was not seriously questioned until a review by Pototschnig2 suggested that the fibroelastic tissue overgrowth was a noninflammatory process. The problem was carefully investigated by Gross,3 who concluded that the lesion should be viewed as a disorder of development. Since then it
HUDSON JB, WHITCOMB JF, JUDSON WE, et al. ADULT ENDOCARDIAL FIBROELASTOSIS: REPORT OF A CASE MIMICKING MITRAL STENOSIS1. Ann Intern Med. 1959;51:151–162. doi: 10.7326/0003-4819-51-1-151
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Published: Ann Intern Med. 1959;51(1):151-162.
Cardiology, Valvular Heart Disease.
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