J. J. RUPP, M.D.; C. CHAVARRIA, M.D.; K. E. PASCHKIS, M.D.; EUGENIE CHUBLARIAN, M.D.
The occurrence of nontoxic goiter in endemic goiter areas can be attributed to iodine deficiency. However, the etiology of nontoxic goiters in euthyroid people in areas not deficient in iodine remains obscure. Rare causes of goiter in people living in such areas are the ingestion of naturally occurring goitrogens (struma cibaria),1 or the use of agents such as sulfonamides, thiocyanate2 and resorcinol,3 among others. In these instances the responsible agent interferes with iodide metabolism in the thyroid, with a resultant decrease in the production of thyroid hormones. The occurrence of goiter associated with cretinism as an inborn error of metabolism
RUPP JJ, CHAVARRIA C, PASCHKIS KE, et al. THE OCCURRENCE OF TRI-IODOTHYRONINE AS THE ONLY CIRCULATING THYROID HORMONE1. Ann Intern Med. 1959;51:359–362. doi: 10.7326/0003-4819-51-2-359
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Published: Ann Intern Med. 1959;51(2):359-362.
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