SOLOMON PAPPER, M.D.; JOSEPH L. BELSKY, M.D.; KENNETH H. BLEIFER
In 1863 Austin Flint first called attention to the presence of oliguria in patients with cirrhosis of the liver and hydroperitoneum.1 Since that time it has become quite apparent that oliguria is extremely common in patients with cirrhosis and marked ascites. This decreased urine flow is generally not associated with striking diminution in glomerular filtration rate (GFR) or rise in blood nonprotein nitrogen concentration;2 rather, the oliguria is usually attributable to the decreased solute load, especially sodium, that is presented for excretion. However, in some instances, decreased urine flow in patients with cirrhosis is accompanied by azotemia. While we have
PAPPER S, BELSKY JL, BLEIFER KH. RENAL FAILURE IN LAENNEC'S CIRRHOSIS OF THE LIVER. I. DESCRIPTION OF CLINICAL AND LABORATORY FEATURES*. Ann Intern Med. 1959;51:759–773. doi: https://doi.org/10.7326/0003-4819-51-4-759
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Published: Ann Intern Med. 1959;51(4):759-773.
Gastroenterology/Hepatology, Liver Disease, Nephrology.
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