DAVID P. EARLE, M.D., F.A.C.P.; ROBERT B. JENNINGS, M.D.
Uncertainties and disagreements still complicate consideration of diseases that affect primarily the glomerulus. Although specific therapy is not at hand, accurate classification and clear concepts of the natural histories of these diseases contribute significantly to their understanding, practical clinical management and prognosis.
The keystone of our approach to this problem is a correlation of the clinical course with serial histologic observations in 36 adults with sporadic acute glomerulonephritis whose disease followed proved hemolytic streptococcal infection (table 1). Recovery of group A hemolytic streptococci on culture, and/or a significant increase in serum antistreptolysin, antistreptokinase or antihyaluronidase titers on serial measurements, were
EARLE DP, JENNINGS RB. STUDIES OF POSTSTREPTOCOCCAL NEPHRITIS AND OTHER GLOMERULAR DISEASES12. Ann Intern Med. 1959;51:851–860. doi: 10.7326/0003-4819-51-5-851
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Published: Ann Intern Med. 1959;51(5):851-860.
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