NEMAT O. BORHANI, M.D.
Trimethidinium methosulfate is an asymmetric bisquaternary amine, possessing ganglionic blocking properties but demonstrating, in addition, a central component of antihypertensive activity.1 The pharmacology of trimethidinium methosulfate has been studied by Klupp2 and by Eckfeld et al.,3 and its structural formula is shown in figure 1.
The antihypertensive action of this compound has been studied by O'Malley et al. It has been claimed that trimethidinium methosulfate has "hypotensive potency in excess of any quaternized ganglioplegic agents presently in use."4 Furthermore, it has been observed that the ganglionic blockade produced by trimethidinium methosulfate does not necessarily parallel its hypotensive effects. In an
BORHANI NO. USE OF TRIMETHIDINIUM METHOSULFATE (A NEW GANGLIONIC BLOCKING AGENT) IN THE TREATMENT OF HYPERTENSION123. Ann Intern Med. 1959;51:983–992. doi: 10.7326/0003-4819-51-5-983
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Published: Ann Intern Med. 1959;51(5):983-992.
Cardiology, Coronary Risk Factors, Hypertension, Nephrology.
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