GEORGE F. WILGRAM
Despite extensive research, no proved concept of the etiology of Laennec's cirrhosis has yet been established. Cirrhosis has been produced experimentally by different means in several species (mice, rats, guinea pigs, rabbits, dogs).1-21 However, some pathologists have contended that the resulting lesions lack certain criteria that permit the diagnosis of Laennec's cirrhosis and would not allow any application to man. It was therefore felt that an experimental reproduction of Laennec's cirrhosis in primates might shed some light on this complex problem in man. Little work has been done so far on primates. After numerous failures using various abnormal diets on
WILGRAM GF. EXPERIMENTAL LAENNEC TYPE OF CIRRHOSIS IN MONKEYS1. Ann Intern Med. 1959;51:1134–1158. doi: 10.7326/0003-4819-51-6-1134
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Published: Ann Intern Med. 1959;51(6):1134-1158.
Gastroenterology/Hepatology, Liver Disease.
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