E. CLINTON TEXTER JR., M.D., F.A.C.P.; GASTON R. VANTRAPPEN, M.D.; HAROLD P. LAZAR, M.D.; ERNESTO J. PULETTI, M.D.; CLIFFORD J. BARBORKA, M.D., F.A.C.P.
Direct chemical irritation by hydrochloric acid and disordered motor activity of the stomach and duodenum have been implicated in the causation of ulcer pain. The presence or absence of vascular engorgement of the mucosa in the region of the ulcer has also been related to ulcer pain. Many investigators have tended to support one or the other points of view without implicating other factors. Although the concept of direct chemical irritation has been the more commonly accepted one among gastroenterologists, physiologists have maintained that the mechanism for pain arising from any of the hollow viscera is some disorder of motor
TEXTER EC, VANTRAPPEN GR, LAZAR HP, et al. FURTHER OBSERVATIONS ON THE MECHANISM OF ULCER PAIN123. Ann Intern Med. 1959;51:1275–1294. doi: 10.7326/0003-4819-51-6-1275
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Published: Ann Intern Med. 1959;51(6):1275-1294.
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