PHILLIP L. ROSSMAN, M.D.; GEORGE J. HUMMER, M.D.
The literature is replete with articles on the use of steroids in the treatment of drug-induced agranulocytosis but not with articles on nondrug-induced, non-cyclic, nonsplenic neutropenia. Two cases of the latter type in siblings are presented, in the second of whom a favorable response to steroid therapy was obtained.
The mother of these children has a duodenal ulcer and disseminated lupus erythematosus, currently controlled with the use of prednisone. Her blood count and peripheral blood picture have always been normal. Examination of her bone marrow revealed numerous L.E. cells of the Hargraves' type. The children's father had had a coronary
ROSSMAN PL, HUMMER GJ. CHRONIC NEUTROPENIA IN SIBLINGS: THE EFFECT OF STEROIDS1. Ann Intern Med. ;52:242–254. doi: 10.7326/0003-4819-52-1-242
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Published: Ann Intern Med. 1960;52(1):242-254.
Hospital Medicine, Infectious Disease, Lupus Erythematosus, Rheumatology.
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