JOHN J. CASTELLOT; ROBERT L. CREVELING; FORREST W. PITTS
Experience with ACTH, hydrocortisone and similar compounds during the last decade has repeatedly shown the risk of using these agents in large doses over long periods.1, 2 This has been particularly true in tuberculosis and histoplasmosis, and in infections when its use is not accompanied with antimicrobial therapy.3, 4 The following case is believed to be the first to document the deleterious effects of adrenocortical steroid therapy on clinical coccidioidomycosis.
In the third trimester of her first pregnancy, in 1950, this 37 year old white female was hospitalized for preeclampsia and found to have hepatosplenomegaly, anemia, neutrophilia with
CASTELLOT JJ, CREVELING RL, PITTS FW. FATAL MILIARY COCCIDIOIDOMYCOSIS COMPLICATING PROLONGED PREDNISONE THERAPY IN A PATIENT WITH MYELOFIBROSIS*. Ann Intern Med. 1960;52:254–258. doi: https://doi.org/10.7326/0003-4819-52-1-254
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Published: Ann Intern Med. 1960;52(1):254-258.
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