THEODORE RODMAN, M.D.; HENRY P. CLOSE, M.D., F.A.C.P.; MAY K. PURCELL
The primary function of hemoglobin is the transport of oxygen from the lungs to the tissues. Anemia compromises this transport mechanism and exposes the tissues to the dangers of hypoxia. The fact that patients with slowly developing anemia are frequently symptom-free with low levels of circulating hemoglobin strongly suggests that efficient compensatory mechanisms are available to provide an adequate supply of oxygen to the tissues. There are two generally recognized compensatory mechanisms: a reduced tissue oxygen tension, which results in more nearly complete extraction of oxygen from the blood, and an increased cardiac output. Both of these mechanisms entail disadvantages—a
RODMAN T, CLOSE HP, PURCELL MK. THE OXYHEMOGLOBIN DISSOCIATION CURVE IN ANEMIA1. Ann Intern Med. ;52:295–309. doi: 10.7326/0003-4819-52-2-295
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Published: Ann Intern Med. 1960;52(2):295-309.
Hematology/Oncology, Red Cell Disorders.
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