EDWARD R. BURKA
It is now recognized that there are at least two distinct types of chronic nonhemolytic jaundice characterized by a benign prognosis and a familial tendency. In the first of these, described by Gilbert in 1902,1 there is an elevated serum bilirubin of the indirect-reacting type, normal bromsulfalein excretion, negative cephalin flocculation and thymol turbidity tests, and normal liver morphology and oral cholecystography.2 In the second type, described by Dubin and Johnson3 and Sprinz and Nelson4 in 1954, the serum bilirubin is both indirect- and direct-reacting. This latter condition, termed chronic idiopathic jaundice with unidentified pigment in the liver cells,5
BURKA ER. STUDIES IN A CASE OF CHRONIC IDIOPATHIC JAUNDICE1. Ann Intern Med. 1960;52:453–459. doi: 10.7326/0003-4819-52-2-453
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Published: Ann Intern Med. 1960;52(2):453-459.
Lupus Erythematosus, Rheumatology.
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