J. R. FOUNTAIN, M.D., M.R.C.P. (Edin.); R. L. HOLMAN, M.B., Ch.B.
Carcinoma may lead to anemia, leukopenia, thrombocytopenia and the appearance of a leuko-erythroblastic blood picture, but only in rare instances have disorders of blood coagulation been observed. Stefanini1 and Cosgriff and Leifer2 have recorded cases of Factor V deficiency associated with advanced carcinoma, while Jürgens and Trautwein3 and, more recently, Swan and his associates,4 have reported a severe hemorrhagic diathesis due to fibrinogen deficiency in patients with advanced carcinoma of the prostate.
It is the purpose of this paper to report the occurrence of a bleeding disorder due to fibrinogen deficiency in a patient with bronchial carcinoma.
FOUNTAIN JR, HOLMAN RL. ACQUIRED FIBRINOGEN DEFICIENCY ASSOCIATED WITH CARCINOMA OF THE BRONCHUS*. Ann Intern Med. 1960;52:459–463. doi: https://doi.org/10.7326/0003-4819-52-2-459
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Published: Ann Intern Med. 1960;52(2):459-463.
Coagulopathies, Hematology/Oncology, Lung Cancer, Pulmonary/Critical Care.
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