ETHAN A. H. SIMS, M.D., F.A.C.P.
Recent studies of renal function in normal pregnancy have indicated that the renal plasma flow and glomerular filtration rate are increased roughly 50 and 30% respectively, particularly during midpregnancy.1, 2 It is known that diabetic patients may enter pregnancy with renal function impaired as a result of intercapillary glomerulosclerosis (Kimmelstiel-Wilson syndrome), but may nevertheless successfully complete pregnancy without further deterioration of renal function, although in general the presence of nephritis places the patient in a relatively poor prognostic category.3 However, little is known about the course of pregnancy with respect to renal function in these patients and how it
SIMS EAH. RENAL FUNCTION DURING PREGNANCY COMPLICATED BY INTERCAPILLARY GLOMERULOSCLEROSIS: SERIAL STUDIES IN A YOUNG DIABETIC1. Ann Intern Med. 1960;52:693–702. doi: 10.7326/0003-4819-52-3-693
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Published: Ann Intern Med. 1960;52(3):693-702.
Cardiology, Coronary Risk Factors, Diabetes, Diabetic Nephropathy, Endocrine and Metabolism.
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