HARRY BARTFELD, M.D.
Our laboratory and others using various technics for demonstrating "rheumatoid arthritis factor" have found impressive numbers of seropositives in nonrheumatoid, noncollagen diseases. Miller et al.6 in 1949, and Craig et al.20 in 1957, inferred that the sensitized sheep cell test was not diagnostic of any specific disease entity. Dresner30, a, b in 1958 and 1959 performed extensive studies with the Fraction II Latex Fixation Test, and feels that the rheumatoid agglutinating factor is not specific.
It should be remembered that Meyer1 in 1922 found that a serum of a cirrhotic patient strongly agglutinated sheep and guinea pig cells sensitized with
BARTFELD H. INCIDENCE AND SIGNIFICANCE OF SEROPOSITIVE TESTS FOR RHEUMATOID FACTOR IN NONRHEUMATOID DISEASES1. Ann Intern Med. ;52:1059–1066. doi: 10.7326/0003-4819-52-5-1059
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Published: Ann Intern Med. 1960;52(5):1059-1066.
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