ROGER M. DES PREZ, M.D.; CLARENCE W. JORDAHL, M.D.
Prior to effective drug therapy, tuberculous meningitis was rapidly and invariably fatal. It is not surprising, therefore, that the impact of effective chemotherapy was most dramatically demonstrated in this form of the disease. To cite from one large experience,1 the survival rate, which was zero in 1946, rose with the advent of streptomycin and isoniazid to over 90% less than 10 years later. When survival became the rule, the entirely new problem of crippling sequelae to the disease emerged. It became apparent that a small but significant number of patients lived only to be permanently and severely disabled by the
DES PREZ RM, JORDAHL CW. THE PROBLEM OF OPTIC ATROPHY COMPLICATING TUBERCULOUS MENINGITIS1. Ann Intern Med. 1960;52:1118–1123. doi: 10.7326/0003-4819-52-5-1118
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Published: Ann Intern Med. 1960;52(5):1118-1123.
DOI: 10.7326/0003-4819-52-5-1118
CNS Infections, Infectious Disease, Mycobacterial Infections, Neurology.