LEO WAITZKIN, M.D.
This report issues from studies concerning the pathogenesis of hepatic dysfunction due to chlorpromazine, the prophylactic and therapeutic influence thereon of synthetic adrenocortical hormones, and trials of deliberate desensitization.
All of the patients studied had been hospitalized for neuropsychiatric illnesses, were in good physical health, and had no debilitating disease. Chlorpromazine was administered to them orally.
The same battery of liver function tests was employed throughout the studies. It was composed of thymol turbidity, zinc turbidity, cephalin flocculation,a bromsulfalein retention,b serum glutamic-oxalacetic transaminasec and usually serum glutamic-pyruvic transaminase,d serum alkaline phosphatase,e total serum bilirubinf and prompt, direct-reacting bilirubin.g After the
WAITZKIN L. PROBABLE HEPATIC ALLERGY TO CHLORPROMAZINE AND DELIBERATE DESENSITIZATION1. Ann Intern Med. 1960;53:116–146. doi: 10.7326/0003-4819-53-1-116
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Published: Ann Intern Med. 1960;53(1):116-146.
Hospital Medicine, Infectious Disease, Prevention/Screening, Vaccines/Immunization.
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