B. I. KORELITZ; H. D. JANOWITZ
In the natural course of ulcerative colitis, serious colonic complications may be expected in from 5 to 10% of the cases.1 These have consisted of free perforation, pericolonic abscess, peritonitis, massive hemorrhage and carcinoma. Not previously included in this group is a rapidly developing and striking dilatation of the colon associated with extreme toxicity. The abdomen becomes distended and usually silent. Though potentially reversible, this ominous sign markedly increases the likelihood that a perforation has occurred.
Single examples of this entity were first described by Marshak et al.2 as "megacolon, a complication of ulcerative colitis," and by Madison and Bargen3
KORELITZ BI, JANOWITZ HD. DILATATION OF THE COLON, A SERIOUS COMPLICATION OF ULCERATIVE COLITIS*. Ann Intern Med. 1960;53:153–163. doi: https://doi.org/10.7326/0003-4819-53-1-153
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Published: Ann Intern Med. 1960;53(1):153-163.
Gastroenterology/Hepatology, Inflammatory Bowel Disease.
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