J. METZ, M.D., B.Ch.; H. R. KLEIN, M.B., B.Ch., M.R.C.P., M.R.C.P.E.
While the nature of erythremic myelosis (di Guglielmo's disease) remains controversial, it is not surprising that the diagnosis may give rise to considerable difficulty. The differentiation from various forms of hemolytic anemia and from severe cases of pernicious anemia presents well recognized difficulties. The application of diagnostic aids of more recent development has been limited by the rarity of the disease; this limitation would seem to warrant the presentation of a case of erythremic myelosis where the red cell survival and serum vitamin B12 content were estimated, and a cytochemical abnormality in the marrow normoblasts, of possible diagnostic value, was
METZ J, KLEIN HR. OBSERVATIONS ON A CASE OF ERYTHREMIC MYELOSIS1. Ann Intern Med. ;53:207–215. doi: 10.7326/0003-4819-53-1-207
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Published: Ann Intern Med. 1960;53(1):207-215.
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