PAUL W. CLOUGH, M.D.
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It has long been common knowledge that if skin is grafted on human subjects, only autografts, from the same individual, survive. Homografts, from other individuals of the same species, are rejected except when the donor and recipient are identical twins with exactly the same antigens. This has been found true of all vertebrates studied, from fish to monkeys.
If some means could be found to circumvent this process of rejection of the graft, it would be a therapeutic triumph of major importance. It should make possible not merely homografts of skin but of tissues generally, including the transplantation of intact
CLOUGH PW. IMMUNITY TO TISSUE GRAFTS. Ann Intern Med. ;53:228–236. doi: 10.7326/0003-4819-53-1-228
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Published: Ann Intern Med. 1960;53(1):228-236.
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