JOHN H. LARAGH; STANLEY ULICK; VLODZIMIERZ JANUSZEWICZ; WILLIAM G. KELLY; SEYMOUR LIEBERMAN
The fundamental relationship between intravascular pressure and electrolyte metabolism is poorly understood. The hormones of the adrenal cortex which act to regulate sodium and potassium balance can produce hypertension both in man and in experimental animals.1, 2 The hypertensive state produced by adrenal mineralocorticoids such as desoxycorticosterone is dependent upon administration of adequate amounts of sodium in the diet, whereas the hypertension induced by glucocorticoids such as hydrocortisone differs in that it is less severe, and it is not dependent upon sodium intake.3
Aldosterone, though more potent, produces effects on sodium and potassium metabolism similar to those of desoxycorticosterone. Aldosterone
LARAGH JH, ULICK S, JANUSZEWICZ V, et al. ELECTROLYTE METABOLISM AND ALDOSTERONE SECRETION IN BENIGN AND MALIGNANT HYPERTENSION*†. Ann Intern Med. 1960;53:259–272. doi: https://doi.org/10.7326/0003-4819-53-2-259
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Published: Ann Intern Med. 1960;53(2):259-272.
Cardiology, Coronary Risk Factors, Hypertension, Nephrology.
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