MARJORIE S. SIRRIDGE, M.D.
Primary macroglobulinemia is a rare disease which was first described in 1944 by Waldenström.1 Using the ultracentrifuge, he identified abnormal proteins with high sedimentation constants in two patients who had many findings similar to those seen in multiple myeloma. The distinctive features of these cases were anemia, epistaxis, slight lymphadenopathy, lymphocytoid cells in the bone marrow, generalized osteoporosis, and the presence of macroglobulins in the serum. In one of these patients the abnormal globulin also was found to be a cryoglobulin. Since the original description by Waldenström, at least 40 similar case reports have appeared, particularly in the foreign literature.
SIRRIDGE MS. WALDENSTRÖM'S MACROGLOBULINEMIA WITH CRYOGLOBULINEMIA*. Ann Intern Med. 1960;53:380–388. doi: https://doi.org/10.7326/0003-4819-53-2-380
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Published: Ann Intern Med. 1960;53(2):380-388.
Endocrine and Metabolism, Hematology/Oncology, Metabolic Bone Disorders, Red Cell Disorders.
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