DONALD A. HOLUB, M.D.; JOSEPH W. JAILER, M.D., Ph.D.
Cirrhosis of the liver, in common with the nephrotic syndrome and congestive heart failure, is often complicated by the abnormal retention of sodium and water. The underlying pathophysiology is not completely understood, but factors such as hypoproteinemia, elevation in portal or systemic venous pressure, and changes in renal hemodynamics are now known to contribute to the sustained accumulation of sodium and water which is frequently seen in these diseases.
In addition, excessive amounts of a salt-retaining material are present in the urine of patients with hepatic cirrhosis and ascites.1 This substance causes retention of sodium when injected into the adrenalectomized
HOLUB DA, JAILER JW. SODIUM AND WATER DIURESIS IN CIRRHOTIC PATIENTS WITH INTRACTABLE ASCITES FOLLOWING CHEMICAL INHIBITION OF ALDOSTERONE SYNTHESIS*†. Ann Intern Med. 1960;53:425–444. doi: https://doi.org/10.7326/0003-4819-53-3-425
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Published: Ann Intern Med. 1960;53(3):425-444.
Gastroenterology/Hepatology, Liver Disease.
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