JOHN F. NICKERSON; S. RICHARDSON HILL JR., M.D.; JEAN H. MCNEIL, M.D.; SAMUEL B. BARKER, Ph.D.
Relatively few cases of terminal myxedema, especially of myxedema coma, have been reported. The first report of fatal hypothermic coma appeared in 1879.1 The condition was also described in 1888, in the report on myxedema of the Clinical Society of London.2 However, it was not brought to general attention until 1953, when six cases were reported in two series.3, 4 Twenty-four additional case reports have appeared in the last six years.5-21 It is noteworthy that 13 of the 30 case reports have been in four series.
In contrast to the scarcity of reported cases of terminal myxedema, during the
NICKERSON JF, HILL SR, MCNEIL JH, et al. FATAL MYXEDEMA, WITH AND WITHOUT COMA*†. Ann Intern Med. 1960;53:475–493. doi: https://doi.org/10.7326/0003-4819-53-3-475
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Published: Ann Intern Med. 1960;53(3):475-493.
Endocrine and Metabolism, Neurology, Thyroid Disorders.
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